One consequence of acute inflammation is ulceration. This occurs on epithelial One consequence of acute inflammation involving an epithelial surface is ulceration. The inflammation destroys the mucosa, typically in a localized manner. Here the gastric mucosa has been focally lost, or ulcerated. A larger ulcer and several adjacent smaller ones with surrounding erythema appear at the left of center.The destruction of the epithelium can predispose to bleeding, pain, and even extension through the muscular wall of the stomach (perforation).