Perinatal-Pediatric Pathology

For each of the following neonatal histories, select the most closely associated perinatal problem:

1. Following a difficult delivery in which a nuchal cord was present, it is noted that the placenta with fetal membranes, as well as the baby's skin, are stained green. This term baby subsequently develops increasing respiratory difficulty and requires intubation:

2. A baby demonstrating macrosomia is delivered at 36 weeks gestation. The baby looks fine at delivery with good Apgar scores, but soon becomes irritable, then has a generalized seizure, and then becomes obtunded. The baby's serum glucose is 25 mg/dL:

3. A baby is born prematurely at 28 weeks gestational age to a 25-year-old primigravida. Artificial surfactant is administered at birth and the baby remains stable for a couple of days. However, the baby then has several generalized seizures and deteriorates neurologically, eventually developing hydrocephalus a month later:

4. An infant born at term following an uncomplicated pregnancy develops icterus and hypotonia with seizures in the first month of life. On examination the infant has hepatomegaly and cataracts. Laboratory studies show coagulopathy:

5. An infant born at term is noted to pass no meconium in the first 3 days of life. On examination the infant's abdomen is distended:

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A. Cystic fibrosis B. Cytomegalovirus C. Galactosemia D. Gestational diabetes
E. Group B Streptococcus F. Hirschsprung's disease G. Hyaline membrane disease H. Intraventricular hemorrhage
I. Meconium aspiration J. Necrotizing enterocolitis K. Neural tube defect L. Neuroblastoma
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