Immunopathology

For each of the following patient descriptions, select the most likely condition:

1. A mother brings her 3-year-old child to you because she says he seems to be sick half the time and she wants to know what is wrong. The child is normally developed for age and has met all developmental milestones. The child is found to have rhinorrhea and an erythematous right tympanic membrane. The child has never been hospitalized. No anomalies are noted. A CBC reveals a slightly elevated WBC count:

2. A prepubertal man has had recurrent bacterial infections for many years. However, he now develops a fungal infection. Physical examination reveals an eczematous skin rash. He is also found to be thrombocytopenic, with a platelet count of only 75,000/microliter:

3. At birth, a term baby develops hypocalcemia, but this is treated. In the first two years of life, the child is hospitalized multiple times for treatment of infections ranging from candidiasis to cryptococcosis and for viral infections ranging from adenovirus to parainfluenza virus:

4. A 35-year-old man has a history of mild upper respiratory tract infections as well as diarrhea since childhood. Following an accident with blood loss, he receives a transfusion of packed RBCs and develops an anaphylactic transfusion reaction:

5. An 18-month-old child has a history of recurrent infections with multiple bacterial organisms since late infancy. The organisms cultured include Streptococcus pneumoniae, Haemophilus influenzae, and Pseudomonas aeruginosa:

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A. Acquired immunodeficiency syndrome B. Adenine deaminase deficiency C. Chronic granulomatous disease D. Common variable immunodeficiency
E. Complement deficiency F. DiGeorge syndrome G. Fanconi anemia H. Normal child
I. Selective IgA deficiency J. Systemic lupus erythematosus K. Wiskott-Aldrich syndrome L. X-linked agammaglobulinemia
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