This silver stain demonstrates a double contour to many basement membranes, or the "tram-tracking" that is characteristic of membranoproliferative glomerulonephritis (MPGN) that results from basement membrane reduplication.

Question: What serologic test is often positive with MPGN?

AnswerThe C3 nephritic factor (C3NeF) is an autoantibody directed at C3 convertase and often found with MPGN when there is hypocomplementemia.