Here is a renal cell carcinoma that on sectioning is mainly cystic with extensive hemorrhage. Sometimes large simple renal cysts may develop hemorrhage and mimic this appearance.

Question: What gene mutation may be present with renal cell carcinoma?

AnswerAbout 3/4 of sporadic cases have a von Hippel-Lindau (VHL) tumor suppressor gene mutation. Persons with the inherited VHL syndrome are at risk for renal cell carcinoma.