These sections through a prostate removed via radical prostatectomy reveal irregular yellowish nodules, mostly in the posterior portion (seen here superiorly). This proved to be prostatic adenocarcinoma. Prostate glands containing adenocarcinoma are not necessarily enlarged. Adenocarcinoma may also coexist with hyperplasia. However, prostatic hyperplasia is not a premalignant lesion. Staging of prostatic adenocarcinoma is based upon how extensive the tumor is.