This is another example of granulomatous disease of the lung. The pattern of smaller nodules which have a propensity for upper lobe involvement suggests a granulomatous process rather than metastatic disease.

Which of the following has the greatest specificity for Mycobacterium tuberculosis?

A High-resolution CT imaging

B Interferon gamma release assay

C Skin test with purified protein derivative

C Sputum smear for acid fast bacilli