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Module 5: Transfusion Medicine: Practice Questions

1. (Concept T1b) A 38-year-old woman with a history of immune thrombocytopenic purpura (ITP) has been treated with corticosteroid therapy for the past year. She has had a cough for the past month, and a chest radiograph shows a right lower lung nodule. Fine needle aspiration biopsy of this nodule is proposed. A platelet count in this woman below which of the following levels should indicate the need for platelet transfusion prior to this procedure?

A. 50,000/microliter

B. 100,000/microliter

C. 150,000/microliter

D. 200,000/microliter

2. (Concept T4) A 37-year-old woman with acute myelogenous leukemia receives chemotherapy. She develops pancytopenia and requires multiple blood product transfusion with packed red blood cells and platelets. She then develops the sudden onset of fever with tachycardia a day following the last transfused unit. Which of the following transfusion-associated infections has she most likely acquired?

A. Hepatitis B

B. Hepatitis C

C. HIV-1

D. Plasmodium falciparum

E. Staphylococcus aureus

3. (Concept T6) A 58-year-old man comes to the emergency department with worsening fatigue and maroon-colored stools for the past day. On examination his blood pressure is 80/40 mm Hg. His oxygen saturation is 50%. His Hct is 17%. His electronic medical record documents his blood type from testing last year as type A positive. Which of the following orders for packed red blood cells is most appropriate for this man?

A. Type and screen for type A positive cells

B. Type and cross for type A positive cells

C. Emergent release of type A positive cells

D. Type and screen for type O negative cells

E. Type and cross for type O negative cells

F. Emergent release of type O negative cells

4. (Concept T8) A 22-year-old gravida 2 para 1 woman is at 17 weeks gestation. She notes minimal fetal movement. Fetal ultrasound examination shows fetal hydrops. The maternal blood type is A negative. Which of the following test results on maternal blood is most likely to be present?

A. Decreased haptoglobin

B. Decreased unconjugated estriol

C. Increased alpha-fetoprotein

D. Increased bilirubin

E. Positive indirect Coombs test

F. Positive serologic test for HIV

5. (T9) A 45-year-old man with selective IgA deficiency has a severe anemia. He requires transfusion therapy. Which of the following is recommended to decrease the risk for transfusion reaction in this man?

A. Autologous blood

B. Gamma irradiation

C. Leukoreduction filtration


E. Washed red blood cells

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